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Supernatural stars Jensen Ackles and Jared Padalecki as Dean and Sam Winchester, two brothers who travel the country looking for their missing father and battling evil spirits along the way.

Sam Winchester is a college student bound for law school, determined to escape his family's past - unlike his older brother, Dean. Ever since they were little their father has been consumed with an obsession to find the evil forces that murdered his beloved wife, in result recruiting and training his two young sons to help him in revenge. They have grown up as hunters of the supernatural. Sam escaped under the premise of going to college, and now has a happy life with his girlfriend, Jessica, and a promising future career. Dean, however, stayed behind with his father to join him in his "hunting".

Dean goes to Sam for help when their father goes missing. Now Sam must join his brother to find him. His one weekend trip to search for the missing John Winchester becomes an ongoing quest after a horrible tragedy ruins any thought of a happy life for Sam.

The two brothers, bound by tragedy and blood to their mission, travel across the country encountering terrifying and dangerous forces most believe to be nothing but superstition and folklore, such as the Lady in White, the Indian beast known as the Wendigo, Phantom Travelers who cause plane crashes, Bloody Mary, vampires, demons and many more.